Sysmex XN-9000 Series Fully Automated Blood Analysis Pipeline

Sysmex XN-9000 Series Fully Automated Blood Analysis Pipeline

Overall system architecture (modular pipeline)

XN-9000 is a modular blood automation assembly line that can be expanded step by step, and can be arranged in linear, L-shaped, and U-shaped configurations, suitable for existing laboratory buildings without the need for large-scale renovation. The entire system can be freely combined by the following modules:

XN series blood analyzer (XN-10, XN-20)

XN-10 (green panel): Standard CBC+SIFF+NRBC (complete blood count+five categories+nucleated red blood cells)

XN-20 (blue panel): Standard CBC+SIFF+NRBC+RET reticulocytes+WPC immature cell count

SP-10 fully automatic slide staining machine: automatically optimizes slide conditions based on sample hematocrit HCT; Only samples that meet the preset rules are used to make blood smears, reducing invalid slides.

DI-60 digital morphology analyzer: automatically collects blood cell images and pre classifies them; Support remote reading software, morphological experts can remotely review and consult; Assessing the interpretation level of personnel using web capability verification tools; Reduce neck, wrist, and eye fatigue caused by traditional microscopes.

TS-10 Sample Sorting and Archiving Module: Sort and archive abnormal samples; Upgradeable kit improves sorting speed and capacity, protecting initial equipment investment; Shorten the report turnover time TAT.

RU-20 reagent unit (optional): Large capacity reagent, reduces replacement frequency, reduces manual handling, saves storage space, and improves instrument start-up rate.

Basic configuration performance reference: 3 XN analyzers can perform up to 300 tests per hour; SP-10 has a maximum of 120 smears per hour; DI-60 up to 30 smears per hour; The basic version of TS-10 has 500 tubes per hour, and after upgrading, it can reach 1000 tubes per hour.

Efficiency Characteristics - Unmanned Production Line

Truly walk away unmanned operation: operators only need to load and unload samples; The instrument automatically completes the entire process of sample loading, analysis, reflection detection, slide staining, cell pre classification, sample sorting and archiving, freeing up manpower to handle complex tasks.

Single control switch for overall machine startup; The process of sample loading, detection, reflection testing, film production, sorting and archiving will not interrupt the operation of the assembly line.

Reflex: The instrument automatically retests or triggers additional testing on abnormal or unreliable samples according to laboratory preset rules.

Advantages: Good repeatability of results, shortened TAT; Minimize manual intervention to the greatest extent possible; Unified standardized sample processing procedures.

Follow the testing tasks assigned by the LIS laboratory information system.

Rich clinical parameters (Informative), laser flow cytometry detection principle

The instrument uses laser flow cytometry to classify blood cell counts, and the algorithm identifies white blood cells, red blood cells, and platelets, and marks abnormal cell populations; Multiple advanced parameters are used to assist in the assessment of various diseases:

NRBC nucleated red blood cells (standard, output from each CBC report)

Prompt for erythroid hematopoietic stress, thalassemia, and myeloproliferative disorders; Severe patients with NRBC indicate poor prognosis;

The maximum linear range is 600 NRBC/100WBC; Detecting NRBC will automatically correct the WBC white blood cell count; No need for additional manual testing, saving costs and improving turnaround time.

IG immature granulocytes (standard, DIFF five classification output, achieving six classifications)

Including late immature grains, medium immature grains, and early immature grains; Distinguish between SIRS systemic inflammatory response syndrome and sepsis; Monitor the effectiveness of infection and inflammation treatment; Reduce the workload of manual smear microscopy.

IPF immature platelet fraction (PLT-F channel)

IPF reflects the status of platelet production: low IPF indicates insufficient platelet production; High IPF indicates increased peripheral platelet destruction; Used to identify the causes of thrombocytopenia; Evaluate bone marrow recovery and guide platelet transfusion strategies.

HPC artificial blood progenitor cells (WPC specific measurement mode, optional)

Good comparability with CD34 flow cytometry results; Quickly determine the optimal timing for collecting peripheral blood stem cells for PBSCT, saving process resources.

BF Fluid Mode (optional)

Fluid samples such as cerebrospinal fluid, synovial fluid, pleural effusion, CAPD dialysate, etc; No need for sample pre-treatment or additional reagents; Output mononuclear MN/multi-core PMN binary classification, quickly distinguish viral and bacterial infections, and assist clinical decision-making; Standardization replaces manual microscopy to reduce human error.

RET-He reticulocyte hemoglobin content (optional, reticulocyte item)

Reflect the bioavailability of iron in the body and distinguish between absolute iron deficiency and functional iron deficiency; Monitor the response to EPO erythropoietin and intravenous iron therapy; Supporting IRF immature reticulocytes Hypo‑He、Hyper‑He， Assist in the classification of various types of anemia.

XN-CBC and XN-DIFF are essential basic modules; RET, PLT-F, WPC, BF, HPC are all optional authorization functions that can be activated as needed in the future without the need for hardware replacement.

Upgradability modular concept

Additional hardware modules in the later stage: After purchasing the basic assembly line, the subsequent business growth can directly increase the analyzer, SP-10, DI-60, TS-10, and RU-20 modules to protect the initial investment. The assembly line supports straight, L-shaped, and U-shaped layouts, suitable for laboratory columns and water supply and drainage points, without the need for large-scale decoration and renovation.

Step by step activation of software functions: advanced applications such as RET, PLT-F, BF body fluids, HPC progenitor cells, etc. The hardware of the instrument is already in place at the factory, and only needs to be authorized as needed and connected to the corresponding reagents to enable it, without the need to replace the analyzer body.

Positioning of Same Family Product Line:

Model positioning

XN-1000 entry-level fully automatic assembly line, integrated reflection detection, improves work efficiency

XN-3000 compact automated assembly line, built-in slide dyeing module, standardized process

XN-2000 load balancing, balancing both conventional and special sample detection

XN-9000 fully scalable advanced assembly line, meeting complex and diverse clinical needs, optimizing the entire process