Sysmex XN-1000/XN-2000 Hematology Analyzer

Sysmex XN-1000/XN-2000 Hematology Analyzer

Product hardware configuration

The XN standalone machine consists of analysis modules XN-10 and XN-20.

Module differences

XN-10: Basic module;

XN-20: Advanced module, unique WPC (leukocyte precursor cell) channel, can activate HPC (artificial blood progenitor cell) detection function.

Whole machine combination scheme

Detection speed: up to 200 samples per hour;

Dual module load automatic balancing; Support reagent sharing mode; For a unique collaborative work architecture.

Detection speed: up to 100 samples per hour;

Built in judgment rules, supporting custom retesting and reflex detection; Customizable clinical applications.

XN-1000: Single XN-10 analysis module; Suitable for laboratories with low sample sizes and diverse clinical needs.

XN-2000: Parallel connection of dual XN-20 analysis modules; Suitable for high-throughput laboratories.

Core detection technology

The whole machine is based on laser flow cytometry, combined with fluid focusing impedance method and cyanide free SLS hemoglobin method.

Laser flow cytometry (633nm laser) collects three types of light signals and generates scatter plots for cell classification and abnormal alarm:

FSC forward scattered light: reflects cell size;

SSC lateral scattered light: reflects the internal particle and nuclear structure information of cells;

SFL lateral fluorescence: reflects the type and content of nucleic acids and organelles.

Fluid focused DC impedance method: used for RBC red blood cell, PLT-I impedance method platelet, HCT red blood cell hematocrit detection.

Cyanide free SLS method: Hemoglobin HGB detection.

Detection channels and advanced clinical parameters

Standard configuration channel

WNR channel (XN-CBC) completes CBC, directly measures nucleated red blood cell NRBC, and corrects WBC results; Scatter plot distinguishes WBC, NRBC, BASO basophils, platelet aggregation, and fragments.

WDF channel (XN-DIFF) classifies six types of white blood cells, including immature granulocytes IG # and IG%; Identify abnormal white blood cell populations such as left shift and abnormal lymphocytes, and generate alarm markers.

WPC channel (XN-20 module only, XN-2000) is a precursor cell channel for white blood cells, specifically labeling primitive cells and abnormal lymphocytes; After software activation, it supports HPC artificial blood progenitor cell counting.

Optional application modules

BF Fluid Mode Body Fluid

Applicable samples: cerebrospinal fluid, peritoneal dialysis fluid, synovial fluid, serosal fluid;

No need for additional reagents or special sample pretreatment;

Output 7 report parameters: WBC-BF, MN (mononuclear cells #/%), PMN (polymorphonuclear cells #/%) TC‑BF、RBC‑BF；

Implement binary classification of body fluids to assist in distinguishing viral/bacterial infections.

RET reticulocyte module detects RET #, RET%, LFR/MFR/HFR (low/medium/high fluorescence reticulocytes), IRF immature reticulocyte fraction, and Ret He reticulocyte hemoglobin equivalent.

Clinical value: Evaluating red blood cell production; Distinguishing iron deficiency types; Monitor the therapeutic effect of EPO erythropoietin and intravenous iron.

The PLT-F fluorescent platelet module fluorescence method has a good correlation with CD41/CD61 flow cytometry reference method for platelet counting; Output IPF immature platelet fraction.

Clinical value: Distinguishing the causes of thrombocytopenia; Early prediction of platelet recovery.

HPC Artificial Blood Progenitor Cells (XN-20 Module Software Activation) Artificial Blood Progenitor Cells HPC #/%; It has a good correlation with CD34 detection and is used to determine the optimal collection timing for peripheral blood stem cell collection in PBSCT.

Parameter List

30 standard report parameters WBC、NRBC#、NRBC%、RBC、HGB、HCT、MCV、MCH、MCHC、RDW‑SD、RDW‑CV、MicroR、MacroR、PLT‑I、PDW、MPV、PCT、P‑LCR； Absolute values and percentages of neutrophils, lymphocytes, monocytes, eosinophils, and basophils; IG#、IG%。

MicroR and MacroR support reporting since software version 21.00.

16 optional parameters RET #, RET%, IRF, LFR/MFR/HFR, Ret He; RBC‑He，Delta‑He，HYPO‑He，HYPER‑He； PLT‑O、PLT‑F； IPF#、IPF%； HPC #/% (only XN-20).

Body fluid mode reports 7 parameters: WBC-BF, MN #, MN%, PMN #, PMN%, TC-BF #, RBC-BF.

Sample suction volume

Sample suction volume mode

Whole blood mode 88 μ L

Pre dilution mode 70 μ L

Fluid BF mode 88 μ L

HPC mode 190 μ L

Quality Control Plan

Routine whole blood cells: Three level quality control product, covering all routine parameters;

Fluid project: Dual level fluid specific quality control product.

Instrument scalability (for future laboratories)

The clinical application module can be retrofitted with software in the later stage without the need to replace hardware, and testing items can be added as the laboratory business expands;

XN-1000 (single module) can be upgraded and transformed into XN-2000 (dual module) in the later stage to cope with the increase in sample size;

The entire XN series shares the same software platform, reducing personnel retraining costs.